Fluorescence Resonance Energy Transfer (FRET) sensor
Syed Arshad Hussain, Dibyendu Dey, Sekhar Chakraborty, Jaba Saha,, Arpan Datta Roy, Santanu Chakraborty, Pintu Debnath, D. Bhattacharjee
TL;DR
This review discusses the extensive applications of FRET in biological and biophysical research, emphasizing recent developments in sensitive, selective ratiometric FRET-based sensors for various analytical and imaging purposes.
Contribution
It provides a comprehensive overview of recent advances in FRET sensor applications, especially in the development of ratiometric sensors for biological and chemical analysis.
Findings
FRET is widely used in structural biology and cellular research.
Recent sensors are highly sensitive and selective.
FRET-based sensors enable advanced bioanalytical techniques.
Abstract
The applications of Fluorescence resonance energy transfer (FRET) have expanded tremendously in the last 25 years, and the technique has become a staple technique in many biological and biophysical fields. FRET can be used as spectroscopic ruler in various areas such as structural elucidation of biological molecules and their interactions, in vitro assays, in vivo monitoring in cellular research, nucleic acid analysis, signal transduction, light harvesting, and metallic nanomaterials etc. Based on the mechanism of FRET a variety of novel chemical sensors and Biosensors have been developed. This review highlights the recent applications of sensitive and selective ratiometric FRET based sensors.
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Taxonomy
TopicsElectrochemical sensors and biosensors