Transient Leadership and Collective Cell Movement in Early Diverged Multicellular Animals

TL;DR

This paper investigates how collective cell movement and decision-making occur in primitive multicellular animals, specifically Trichoplax adhaerens, to understand the rules of cellular coordination and its impact on animal behavior.

Contribution

It provides new insights into collective cell migration and leadership roles in early diverged multicellular animals, a topic not extensively studied before.

Findings

Collective motion in Trichoplax adhaerens demonstrates primitive leadership dynamics.

Cell group size influences migration accuracy and coordination.

Intercellular communication rules affect collective decision-making.

Abstract

Collective motion of cells is critical to some of the most vital tasks including wound healing, development, and immune response [Friedl and Gilmour 2009; Tokarski et al. 2012; Lee et al. 2012; Beltman et al. 2009], and is common to many pathological processes including cancer cell invasion and teratogenesis [Khalil and Friedl 2010]. The extensive understanding of movement by single cells [R{\o}rth 2011; Insall and Machesky 2011; Houk et al. 2012] is insufficient to predict the behavior of cellular groups [Theveneau et al. 2013; Trepat, X. and Fredberg 2011], and identifying underlying rules of coordination in collective cell migration is still evasive. Few of the supposed benefits of collective motion have ever been tested at the cellular scale. As an example, though collective sensing allows for larger groups to exhibit greater accuracy in navigation [Simons 2004; Berdahl et al. 2013] and group taxis is possible through the leadership of only a few individuals [Couzin et al. 2005], such effects have never been investigated in collective cell migration. We will investigate collective motion and decision-making in a primitive multicellular animal, Trichoplax adhaerens to understand how intercellular coordination affects animal behavior and how migration accuracy scales with cellular group size.