Suppression and enhancement of transcriptional noise by DNA looping
Jose M. G. Vilar, Leonor Saiz
TL;DR
This paper provides a quantitative analysis of how DNA looping can both suppress and enhance transcriptional noise, explaining experimental observations and advancing understanding of gene regulation variability.
Contribution
It derives analytical expressions for transcriptional noise quantifiers, elucidating DNA looping's dual role and offering a first quantitative explanation for landmark single-cell measurements.
Findings
DNA looping can both suppress and enhance transcriptional noise
Analytical expressions explain experimental observations
Provides quantitative insights into gene regulation variability
Abstract
DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observations and provide the first quantitative explanation of landmark individual-cell measurements at the single molecule level on the classical lac operon genetic system [Choi et al., Science 322, 442-446 (2008)].
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