Ionic Coulomb Blockade and Resonant Conduction in Biological Ion Channels

TL;DR

This paper introduces ionic Coulomb blockade as a unifying electrostatic model to explain conduction and selectivity in biological ion channels, drawing parallels with quantum dot phenomena.

Contribution

It presents a novel electrostatic approach to explain ion channel behavior, unifying various observed phenomena under ionic Coulomb blockade and resonant conduction.

Findings

Explains conductance and selectivity phenomena in ion channels

Accounts for the anomalous mole fraction effect

Describes discrete conduction bands

Abstract

The conduction and selectivity of calcium/sodium ion channels are described in terms of ionic Coulomb blockade, a phenomenon based on charge discreteness and an electrostatic model of an ion channel. This novel approach provides a unified explanation of numerous observed and modelled conductance and selectivity phenomena, including the anomalous mole fraction effect and discrete conduction bands. Ionic Coulomb blockade and resonant conduction are similar to electronic Coulomb blockade and resonant tunnelling in quantum dots. The model is equally applicable to other nanopores.