Perfluorooctanoic acid rigidifies a model lipid membrane
Beate-Annette Bruening, Bela Farago
TL;DR
This study investigates how perfluorooctanoic acid affects lipid membrane flexibility, revealing that it stiffens membranes similarly to cholesterol, through combined light scattering and neutron spin-echo techniques.
Contribution
It provides new insights into the condensing effect of perfluorinated compounds on lipid bilayers using advanced biophysical methods.
Findings
Perfluorooctanoic acid stiffens lipid membranes.
Membrane stiffening is similar to cholesterol's effect.
Neutron spin-echo reveals reduced bilayer undulations.
Abstract
We report a combined dynamic light scattering and neutron spin-echo (NSE) study on vesicles composed of the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine under the influence of varying amounts of perfluorooctanoic acid. We study local lipid bilayer undulations using NSE on time scales up to 200 ns. Similar to the effect evoked by cholesterol, we attribute the observed lipid bilayer stiffening to a condensing effect of the perfluorinated compound on the membrane.
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