Characteristics of Dispersed ZnO-Folic acid Conjugate in Aqueous Medium

TL;DR

This study investigates the aqueous dispersed properties of ZnO nanoparticles functionalized with folic acid, focusing on their size, optical properties, and suitability for bio-imaging and targeted therapy.

Contribution

It provides detailed characterization of ZnO nanoparticles with folic acid in aqueous media, highlighting their potential for biomedical applications.

Findings

ZnO nanoparticles exhibit broad visible fluorescence.

Surface modification with folic acid enhances bio-compatibility.

Hydrodynamic size supports bio-imaging applications.

Abstract

The focus of this article is based on the aqueous dispersed state properties of inorganic ZnO nanoparticles (average size lessthan or equal to 4 nm), their surface modification and bio-functionalization with folic acid at physiological pH ~ 7.5, suitable for bio-imaging and targeted therapeutic application. While TEM studies of the ZnO nano-crystallites have been performed to estimate their size and morphology in dry state, the band gap properties of the freshly prepared samples, the hydrodynamic size in aqueous solution phase and the wide fluorescence range in visible region have been investigated to establish the fact that the sol is particularly suitable for the bio-medical purpose in the aqueous dispersed state. Key words: ZnO nanoparticle; folic acid; band gap; hydrodynamic size; fluorescence.