Super-resolution photoacoustic imaging through a scattering wall

TL;DR

This paper demonstrates a novel wavefront shaping technique using photoacoustic feedback to achieve super-resolution imaging through scattering walls, significantly improving signal quality and resolution beyond acoustic limits.

Contribution

It introduces a method combining wavefront shaping with photoacoustic feedback to focus light through scattering media without direct access, surpassing traditional resolution limits.

Findings

Achieved up to tenfold SNR improvement.

Realized five to six times sub-acoustic resolution.

Enabled imaging behind scattering media without size limitations.

Abstract

Imaging through opaque, highly scattering walls is a long sought after capability with potential applications in a variety of fields. The use of wavefront shaping to compensate for scattering has brought a renewed interest as a potential solution to this problem. A key to the practicality of any imaging technique is the capability to focus light without direct access behind the scattering wall. Here, we address this problem using photoacoustic feedback for wavefront optimization. By combining the spatially non-uniform sensitivity of the ultrasound transducer to the generated photoacoustic waves with an evolutionary competition among optical modes, the speckle field develops a single, high intensity focus significantly smaller than the acoustic focus used for feedback. Notably, this method is not limited by the size of the absorber to form a sub-acoustic optical focus. We demonstrate imaging behind a scattering medium with up to ten times improvement in signal-to-noise ratio (SNR) and five to six times sub-acoustic resolution. The results presented here open up opportunities for 3D imaging applications in the diffusive regime beyond the sound wave diffraction-limited resolution, including medical imaging, photothermal therapy, neuroscience, and optogenetics.