A Quantum Model on Chemically-Physically Induced Pluripotency in Stem Cells

TL;DR

This paper introduces a quantum model for chemically and physically induced pluripotency in stem cells, calculating transition rates and analyzing factors influencing reprogramming efficiency, aligning well with experimental data.

Contribution

It presents a novel quantum conformational transition model for stem cell reprogramming, linking molecular torsions to pluripotency induction and providing analytical rate formulas.

Findings

Transition rates depend on torsion angles and physical factors.

Calculated characteristic time matches experimental observations.

Decreasing coherence in genes may enhance reprogramming efficiency.

Abstract

A quantum model on the chemically and physically induced pluripotency in stem cells is proposed. Based on the conformational Hamiltonian and the idea of slow variables (molecular torsions) slaving fast ones the conversion from the differentiate state to pluripotent state is defined as the quantum transition between conformational states. The transitional rate is calculated and an analytical form for the rate formulas is deduced. Then the dependence of the rate on the number of torsion angles of the gene and the magnitude of the rate can be estimated by comparison with protein folding. The reaction equations of the conformational change of the pluripotency genes in chemical reprogramming are given. The characteristic time of the chemical reprogramming is calculated and the result is consistent with experiments. The dependence of the transition rate on physical factors such as temperature, PH value and the volume and shape of the coherent domain is analyzed from the rate equation. It is suggested that by decreasing the coherence degree of some pluripotency genes a more effective approach to the physically induced pluripotency can be made.