One-Pot Multi-component Synthesis of 1,4-Dihydropyridine Derivatives in Biocompatible Deep Eutectic Solvents

TL;DR

This paper presents a green, efficient one-pot method for synthesizing 1,4-dihydropyridine derivatives using biocompatible deep eutectic solvents, achieving high yields and good recyclability under solvent-free conditions.

Contribution

It introduces a novel, environmentally friendly protocol for synthesizing 1,4-dihydropyridines with high efficiency and solvent recyclability, advancing sustainable chemical synthesis.

Findings

High yields of 1,4-dihydropyridines achieved

Deep eutectic solvents are recyclable with minimal activity loss

Method operates under solvent-free conditions

Abstract

An efficient protocol for the synthesis of differently substituted 1, 4-dihydropyridines in deep eutectic solvents under solvent-free conditions is reported herewith. Excellent yields of the resultant products have been obtained. Recyclability studies have also been performed for deep eutectic solvents with very little loss in activity up to five recycles.