Single-Base DNA Discrimination via Transverse Ionic Transport
James Wilson, M. Di Ventra
TL;DR
This paper proposes a novel method for DNA sequencing by distinguishing individual bases through measuring ionic currents in a nanochannel, supported by molecular dynamics simulations showing distinct current signatures for each base.
Contribution
It introduces a new approach to DNA sequencing using transverse ionic transport and demonstrates its feasibility through detailed all-atom molecular dynamics simulations.
Findings
Ionic currents differ statistically for each DNA base.
The method offers a potential alternative for DNA sequencing.
Simulations confirm the distinctiveness of ionic signatures.
Abstract
We suggest to discriminate single DNA bases via transverse ionic transport, namely by detecting the ionic current that flows in a channel while a single-stranded DNA is driven through an intersecting nanochannel. Our all-atom molecular dynamics simulations indeed show that the ionic currents of the four bases are statistically distinct, thus offering another possible approach to sequence DNA.
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