Modeling Of Blood Vessel Constriction In 2-D Case Using Molecular Dynamics Method

TL;DR

This study uses molecular dynamics simulations to model blood vessel constriction, demonstrating how increased constriction affects pressure and identifying the point at which vessel leakage begins.

Contribution

It introduces a particle-based molecular dynamics approach to simulate blood vessel constriction, incorporating interaction potentials and plasma viscosity effects.

Findings

Pressure increases with constriction

Leakage begins at 80% constriction

Maximum pressure is observed before leakage

Abstract

Blood vessel constriction is simulated with particle-based method using a molecular dynamics authoring software known as Molecular Workbench (WM). Blood flow and vessel wall, the only components considered in constructing a blood vessel, are all represented in particle form with interaction potentials: Lennard-Jones potential, push-pull spring potential, and bending spring potential. Influence of medium or blood plasma is accommodated in plasma viscosity through Stokes drag force. It has been observed that pressure p is increased as constriction c is increased. Leakage of blood vessel starts at 80 % constriction, which shows existence of maximum pressure that can be overcome by vessel wall.