Maxwell's demon for calcium binding to calmodulin?

TL;DR

This paper questions the claim that calmodulin can directly detect calcium signals by acting as a fast buffer, highlighting doubts about the interpretation of recent experimental results.

Contribution

It critically evaluates recent claims about calmodulin's role in calcium detection, providing a skeptical analysis of the interpretation of experimental data.

Findings

Raises doubts about calmodulin's ability to directly detect Ca2+ signals

Challenges the interpretation of recent experimental results

Suggests need for further investigation into calmodulin's function

Abstract

In the recent paper (2011) Faas and co-workers claimed that calmodulin could directly detect Ca2+ signals by acting as extremely fast calcium buffer. However the results and their interpretation raise serious doubts about this conclusion.