Optimal control of crystallization of alpha-lactose monohydrate

TL;DR

This paper develops a mathematical model for alpha-lactose monohydrate crystallization in semi-batch mode, focusing on controlling process variables to optimize particle size distribution.

Contribution

It introduces a comprehensive model and compares various control strategies to enhance product quality in lactose crystallization.

Findings

Optimal control strategies significantly influence particle size.

Control inputs include temperature, feed rate, and seed selection.

Different cost functions lead to varied product quality outcomes.

Abstract

We present a mathematical model for solvated crystallization of alpha -lactose monohydrate in semi-batch mode. The process dynamics are governed by conservation laws including population, molar and energy balance equations. We present and discuss the model and then control the process with the goal to privilege the production of small particles in specific the range. We compare several specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed.