Arterial stiffening provides sufficient explanation for primary hypertension

TL;DR

This study uses computer models to show that arterial stiffening alone can explain the development of primary hypertension with age, emphasizing a mechanogenic cause over other factors.

Contribution

It demonstrates through modeling that arterial stiffening is sufficient to cause primary hypertension, challenging previous views on its etiology.

Findings

Arterial stiffening explains age-related hypertension.

Impaired baroreflex response is a key factor.

Results align with experimental data.

Abstract

Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite intense research efforts over many decades. By use of empirically well-constrained computer models describing the coupled function of the baroreceptor reflex and mechanics of the circulatory system, we demonstrate quantitatively that arterial stiffening seems sufficient to explain age-related emergence of hypertension. Specifically, the empirically observed chronic changes in pulse pressure with age, and the impaired capacity of hypertensive individuals to regulate short-term changes in blood pressure, arise as emergent properties of the integrated system. Results are consistent with available experimental data from chemical and surgical manipulation of the cardio-vascular system. In contrast to widely held opinions, the results suggest that primary hypertension can be attributed to a mechanogenic etiology without challenging current conceptions of renal and sympathetic nervous system function. The results support the view that a major target for treating chronic hypertension in the elderly is the reestablishment of a proper baroreflex response.