Oscillation in microRNA Feedback Loop
Bin Ao, Sheng Zhang, Caiyong Ye, Lei Chang, Guangming Zhou, Lei Yang
TL;DR
This paper presents a mathematical model demonstrating that microRNA and mRNA can exhibit sustained oscillations in response to external stress, with oscillation periods shorter than traditional feedback loops.
Contribution
It introduces a novel mathematical model showing microRNA-mRNA oscillations as a response to external stress, a phenomenon not previously reported.
Findings
MicroRNA and mRNA levels oscillate under external stress.
Oscillation periods are shorter than known transcriptional feedback loops.
First report of such oscillatory behavior in microRNA-mRNA dynamics.
Abstract
The dynamic behaviors of microRNA and mRNA under external stress are studied with biological experiments and mathematics models. In this study, we developed a mathematic model to describe the biological phenomenon and for the first time reported that, as responses to external stress, the expression levels of microRNA and mRNA sustained oscillation. And the period of the oscillation is much shorter than several reported transcriptional regulation negative feedback loop.
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Taxonomy
TopicsRNA Research and Splicing · Gene Regulatory Network Analysis · MicroRNA in disease regulation