Dynamics of Charge Transfer in Ordered and Chaotic Nucleotide Sequences

TL;DR

This paper investigates charge transfer in DNA-like systems with different nucleotide arrangements, showing that uniform sequences facilitate the most efficient transfer, aligning with experimental observations.

Contribution

It introduces a comparative analysis of charge transfer dynamics in uniform, ordered, and chaotic nucleotide sequences, highlighting the impact of sequence arrangement on transfer efficiency.

Findings

Charge transfer occurs in all sequence types.

Uniform sequences enable the most efficient charge transfer.

Chaotic sequences are least efficient, consistent with experimental data.

Abstract

Charge transfer is considered in systems composed of a donor, an acceptor and bridge sites of (AT) nucleotide pairs. For a bridge consisting of 180 (AT) pairs, three cases are dealt with: a uniform case, when all the nucleotides in each strand are identical; an ordered case, when nucleotides in each DNA strand are arranged in an orderly fashion; a chaotic case, when (AT) and (TA) pairs are arranged randomly. It is shown that in all the cases a charge transfer from a donor to an acceptor can take place. All other factors being equal, the transfer is the most efficient in the uniform case, the ordered and chaotic cases are less and the least efficient, accordingly. The results obtained are in agreement with experimental data on long-range charge transfer in DNA.