On the possibility of electronic DNA nanobiochips

TL;DR

This paper explores the theoretical feasibility of DNA-based nanobiochips that identify sequences through conductance measurements, showing promising recognition capabilities that improve with longer sequences.

Contribution

It introduces a theoretical model for DNA nanobiochips based on conductance differences between single- and double-stranded DNA, aligning with experimental data and predicting high sequence recognition accuracy.

Findings

Double-stranded DNA conductance exceeds single-stranded DNA in most cases.

An 11 nucleotide pair biochip can recognize approximately 97% of sequences.

Recognition accuracy improves with increasing sequence length.

Abstract

We have considered as a theoretical possibility for the development of a nanobiochip the operation principle of which is based on measuring conductance in single-stranded and double-stranded DNA. Calculations have demonstrated that in the majority of cases the conductance of double-stranded nucleotides considerably exceeds that of single-stranded ones. The results obtained are in agreement with recent experiments on measuring the oligonucleotide conductance. It has been shown that an electronic biochip containing 11 nucleotide pairs will recognize approximately 97% sequences. It has also been demonstrated that the percentage of identifiable sequences will grow with the sequence length.