Standardized network reconstruction of CHO cell metabolism
Kieran Smallbone
TL;DR
This paper presents a standardized, genome-scale metabolic network reconstruction of CHO cells, enhancing annotation standards for better dynamic modeling and providing accessible data via ChoNet.
Contribution
The authors developed and improved a comprehensive CHO cell metabolic network with standardized annotations, making it suitable for dynamic modeling and publicly available.
Findings
Enhanced annotation standards for CHO metabolism
Availability of the reconstructed network on ChoNet
Facilitation of dynamic modeling applications
Abstract
We have created a genome-scale network reconstruction of chinese hamster ovary (CHO) cell metabolism. Existing reconstructions were improved in terms of annotation standards, to facilitate their subsequent use in dynamic modelling. The resultant network is available from ChoNet (http://cho.sf.net/).
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Taxonomy
TopicsViral Infectious Diseases and Gene Expression in Insects · Gene expression and cancer classification