Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression

TL;DR

This study investigates how transcription factor binding varies extensively across Drosophila species despite their gene expression patterns remaining highly conserved, highlighting regulatory divergence.

Contribution

It reveals that transcription factor binding divergence is widespread even when gene expression is conserved, providing insights into regulatory evolution.

Findings

Transcription factor binding sites diverge significantly across species.

Gene expression remains highly conserved despite binding divergence.

Regulatory evolution occurs through binding site turnover.

Abstract

Extensive divergence of transcription factor binding in Drosophila embryos with highly conserved gene expression