On-off intermittency of thalamo-cortical oscillations in the electroencephalogram of rats with genetic predisposition to absence epilepsy

TL;DR

This study investigates the temporal dynamics of spike-wave discharges and sleep spindles in rats with absence epilepsy, revealing that both exhibit 'on-off intermittency' behavior, suggesting a shared control mechanism linked to sleep-wake regulation.

Contribution

It demonstrates that SWD and sleep spindles follow 'on-off intermittency' dynamics, providing new insights into their functional relationship and underlying control mechanisms.

Findings

SWD dynamics fit the law of 'on-off intermittency'

Sleep spindles during SWS also show 'on-off intermittency' behavior

High-voltage spindles during intermediate sleep stage have uncertain dynamics

Abstract

Spike-wave discharges (SWD) are electroencephalographic hallmarks of absence epilepsy. SWD are known to originate from thalamo-cortical neuronal network that normally produce sleep spindle oscillations. Although both sleep spindles and SWD are considered as thalamo-cortical oscillations, functional relationship between them is still uncertain. The present study describes temporal dynamics of SWD and sleep spindles as determined in long-term EEG recordings in WAG/Rij rat model of absence epilepsy. It was found that non-linear dynamics of SWD fits well to the law of 'on-off intermittency'. Typical sleep spindles that occur during slow-wave sleep (SWS) also demonstrated 'on-off intermittency' behavior, in contrast to high-voltage spindles during intermediate sleep stage, whose dynamics was uncertain. This implies that both SWS sleep spindles and SWD are controlled by a system-level mechanism that is responsible for regulating circadian activity and/or sleep-wake transitions.