Characteristics of Intronic and Intergenic Human miRNAs and Features of their Interaction with mRNA
Olga Berillo, Assel Issabekova, Mireille Regnier (INRIA Saclay - Ile, de France, LIX), Anatoliy T. Ivashchenko
TL;DR
This study analyzes the interaction patterns of intronic and intergenic human miRNAs with mRNA regions, revealing heterogeneity in binding site distribution and functional region engagement.
Contribution
It provides a detailed comparison of intronic and intergenic miRNA interactions with mRNA, highlighting regional heterogeneity and specific interaction features.
Findings
Interaction features vary across mRNA regions.
Functional regions show heterogeneity in binding site density.
Distinct interaction patterns for intronic and intergenic miRNAs.
Abstract
Regulatory relationships of 686 intronic miRNA and 784 intergenic miRNAs with mRNAs of 51 intronic miRNA coding genes were established. Interaction features of studied miRNAs with 5'UTR, CDS and 3'UTR of mRNA of each gene were revealed. Functional regions of mRNA were shown to be significantly heterogenous according to the number of binding sites of miRNA and to the location density of these sites.
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Taxonomy
TopicsMicroRNA in disease regulation · RNA Research and Splicing · RNA Interference and Gene Delivery