On modelling of bioavailability of drugs in terms of conservation laws

TL;DR

This paper explores how conservation laws can be used to model drug bioavailability, focusing on the pharmacokinetic parameter AUC to provide insights accessible to non-experts.

Contribution

It introduces a conservation law-based approach to understanding drug bioavailability and bioequivalence from fundamental pharmacokinetic principles.

Findings

Simulation of plasma concentration profiles using conservation laws.

Potential to estimate bioavailability from basic pharmacokinetic parameters.

Simplified modeling approach for non-experts.

Abstract

In the text S.Piekarski, M.Rewekant,(arXiv:1208.3847)it has been mentioned that some information on bioavailability and bioequivalence of drugs can be obtained from simulations based on the conservation laws. Here we shortly discuss that possibility starting from the fundamental pharmacokinetic parameter called AUC (Area Under the Curve). The curve is is the profile shape of plasma drug concentration in time intervals after drug administration into organism. Our aim here is to give some information on the subject for the reader with no experience in pharmacokinetics.