Quantum conformational transition in biological macromolecule

TL;DR

This paper introduces a quantum theoretical framework for understanding protein folding, emphasizing the role of molecular torsion as a slow variable and deriving a rate formula that explains temperature dependence and quantum coherence in folding.

Contribution

It presents a novel quantum conformational transition model for protein folding, incorporating torsion dynamics and phase transformations, providing a unified approach to biological conformational changes.

Findings

Derived a quantum-based protein folding rate formula.

Explained non-Arrhenius temperature dependence of folding.

Estimated quantum coherence times in torsional angles.

Abstract

The conformational change of biological macromolecule is investigated from the point of quantum transition. A quantum theory on protein folding is proposed. Compared with other dynamical variables such as mobile electrons, chemical bonds and stretching-bending vibrations the molecular torsion has the lowest energy and can be looked as the slow variable of the system. Simultaneously, from the multi-minima property of torsion potential the local conformational states are well defined. Following the idea that the slow variables slave the fast ones and using the nonadiabaticity operator method we deduce the Hamiltonian describing conformational change. It is proved that the influence of fast variables on the macromolecule can fully be taken into account through a phase transformation of slow variable wave function. Starting from the conformation- transition Hamiltonian the nonradiative matrix element is calculated in two important cases: A, only electrons are fast variables and the electronic state does not change in the transition process; B, fast variables are not limited to electrons but the perturbation approximation can be used. Then, the general formulas for protein folding rate are deduced. The analytical form of the formula is utilized to study the temperature dependence of protein folding rate and the curious non-Arrhenius temperature relation is interpreted. The decoherence time of quantum torsion state is estimated and the quantum coherence degree of torsional angles in the protein folding is studied by using temperature dependence data. The proposed folding rate formula gives a unifying approach for the study of a large class problems of biological conformational change.