Physics of Wound Healing I: Energy Considerations

TL;DR

This paper presents a macroscopic energy-based model of wound healing that predicts healing rates, timescales, and maximum wound mass, validated against experimental data across different conditions.

Contribution

It introduces a novel energy conservation model linking metabolic scaling to wound healing dynamics, providing new predictive insights.

Findings

Wound healing rate peaks at a value determined by metabolic scaling exponent.

Healing time is longer than internal material production timescale by a factor of 1/(1-γ).

Model predicts maximum wound mass based on measurable wound parameters.

Abstract

Wound healing is a complex process with many components and interrelated processes on a microscopic level. This paper addresses a macroscopic view on wound healing based on an energy conservation argument coupled with a general scaling of the metabolic rate with body mass M as M^{\gamma} where 0 <{\gamma}<1. Our three main findings are 1) the wound healing rate peaks at a value determined by {\gamma} alone, suggesting a concept of wound acceleration to monitor the status of a wound. 2) We find that the time-scale for wound healing is a factor 1/(1 -{\gamma}) longer than the average internal timescale for producing new material filling the wound cavity in corresondence with that it usually takes weeks rather than days to heal a wound. 3) The model gives a prediction for the maximum wound mass which can be generated in terms of measurable quantities related to wound status. We compare our model predictions to experimental results for a range of different wound conditions (healthy, lean, diabetic and obsese rats) in order to delineate the most important factors for a positive wound development trajectory. On this general level our model has the potential of yielding insights both into the question of local metabolic rates as well as possible diagnostic and therapeutic aspects.