Few-view single photon emission computed tomography (SPECT) reconstruction based on a blurred piecewise constant object model

TL;DR

This paper introduces a sparsity-exploiting reconstruction algorithm for few-view SPECT imaging that models objects as blurred piecewise constant, demonstrating high accuracy and robustness even with limited projection views.

Contribution

The paper proposes a novel reconstruction algorithm for few-view SPECT that incorporates a blurred piecewise constant object model, showing promising results in noiseless and realistic simulations.

Findings

The algorithm accurately reconstructs objects in noiseless simulations.

It maintains high accuracy with fewer views, with less than 3% variation from 60 to 9 views.

Increased blurring and TV parameters reduce artifacts but lower resolution.

Abstract

A sparsity-exploiting algorithm intended for few-view Single Photon Emission Computed Tomography (SPECT) reconstruction is proposed and characterized. The algorithm models the object as piecewise constant subject to a blurring operation. To validate that the algorithm closely approximates the true object in the noiseless case, projection data were generated from an object assuming this model and using the system matrix. Monte Carlo simulations were performed to provide more realistic data of a phantom with varying smoothness across the field of view. Reconstructions were performed across a sweep of two primary design parameters. The results demonstrate that the algorithm recovers the object in a noiseless simulation case. While the algorithm assumes a specific blurring model, the results suggest that the algorithm may provide high reconstruction accuracy even when the object does not match the assumed blurring model. Generally, increased values of the blurring parameter and TV weighting parameters reduced noise and streaking artifacts, while decreasing spatial resolution. As the number of views decreased from 60 to 9 the accuracy of images reconstructed using the proposed algorithm varied by less than 3%. Overall, the results demonstrate preliminary feasibility of a sparsity-exploiting reconstruction algorithm which may be beneficial for few-view SPECT.