An investigation into the feasibility of myoglobin-based single-electron transistors

TL;DR

This study explores the use of myoglobin proteins in single-electron transistors, demonstrating that proteins with redox centers can facilitate electron transport and serve as components in nanoscale electronic devices.

Contribution

It provides the first proof-of-principle that proteins with redox centers can be used to create single-electron transistors, highlighting the role of protein structure in device performance.

Findings

Single-electron transport mediated by resonant tunneling through heme groups.

Protein orientation and conformation significantly influence conductance.

Proof-of-principle for protein-based single-electron transistors.

Abstract

Myoglobin single-electron transistors were investigated using nanometer- gap platinum electrodes fabricated by electromigration at cryogenic temperatures. Apomyoglobin (myoglobin without heme group) was used as a reference. The results suggest single electron transport is mediated by resonant tunneling with the electronic and vibrational levels of the heme group in a single protein. They also represent a proof-of-principle that proteins with redox centers across nanometer-gap electrodes can be utilized to fabricate single-electron transistors. The protein orientation and conformation may significantly affect the conductance of these devices. Future improvements in device reproducibility and yield will require control of these factors.