On applications of conservation laws in pharmacokinetics

TL;DR

This paper discusses how conservation laws can be applied to improve the formulation of pharmacokinetics, addressing criticisms and proposing a system based on fundamental principles.

Contribution

It introduces a simple conservation law-based model for pharmacokinetics, aiming to resolve inconsistencies in standard formulations.

Findings

Proposes a conservation law framework for pharmacokinetics

Addresses criticisms of existing pharmacokinetic models

Provides a preliminary discussion on the implications of conservation laws

Abstract

There has been certain criticism raised by A. Rescigno [2,8,9,12-15] against the standard formulation of pharmacokinetics. In 2011 it has been suggested that inconsistencies in pharmacokinetics should be eliminated after deriving "pharmacokinetic parameters" from conservation laws [3]. In the following text a simple system of conservation laws for extra - vascular administration of a drug is explicitly given and preliminary discussion concerning this issue is included.