Immunoexpression of Nm23: correlation with traditional prognostic markers in breast carcinoma

TL;DR

This study investigates the expression of Nm23 and its correlation with other prognostic markers in breast carcinoma, revealing inverse relationships with LPA1 and Ki67, and a positive correlation with p53, suggesting complex tumor biology interactions.

Contribution

It provides new insights into the immunoexpression correlations of Nm23 with LPA1, Ki67, and p53 in breast cancer, highlighting potential prognostic implications.

Findings

Nm23 inversely correlates with LPA1 and Ki67.

Nm23 positively correlates with p53.

Significant negative correlation between Nm23/LPA1 and p53.

Abstract

Fifty cases of breast carcinoma were investigated for Nm23, LPA1, Ki67 and p53 antigen expression, using immunohistochemical techniques. Correlation between markers was studied. Nm23 showed an inverse correlation with LPA1 and Ki67, and positive with p53. Nm23/LPA1presented significant (p<0.001) negative correlation with p53, but not difference were observed with Ki67. It can be concluded that: 1) Nm23 and LPA1 tend to be inversely correlated; 2) Nm23 correlates positively with p53, regardless of tumour type and patient's hormonal status; 3) Nm23 shows a reverse trend in comparison with Ki67. However, more studies are needed to determinate if hormone receptors play some role in the inverse relationship between Nm23-LPA1 and to know the tumour type implication in these relationships.