Exploring Neuronal Bistability at the Depolarization Block

TL;DR

This study investigates neuronal bistability between tonic spiking and depolarization block, highlighting the role of Na+ current in bistability, with implications for understanding neuron behavior and drug effects.

Contribution

It demonstrates how Na+ current inactivation influences bistability in neuron models, contrasting dopaminergic and squid axon neurons.

Findings

Bistability exists in dopaminergic neuron models at depolarization block.

Na+ current inactivation primarily characterizes bistability.

Bistability range correlates with Na+ window current.

Abstract

Many neurons display bistability - coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in firing. In this paper, we focus on bistability that allows for a choice between tonic spiking and depolarization block in a wide range of the depolarization levels. We consider the spike-producing currents in two neurons, models of which differ by the parameter values. Our dopaminergic neuron model displays bistability in a wide range of applied currents at the depolarization block. The Hodgkin-Huxley model of the squid giant axon shows no bistability. We varied parameter values for the model to analyze transitions between the two parameter sets. We show that bistability primarily characterizes the inactivation of the Na+ current. Our study suggests a connection between the amount of the Na+ window current and the length of the bistability range. For the dopaminergic neuron we hypothesize that bistability can be linked to a prolonged action of antipsychotic drugs.