Set-valued dynamic treatment regimes for competing outcomes

TL;DR

This paper introduces a novel method for constructing dynamic treatment regimes that recommend sets of treatments to balance multiple competing outcomes, addressing limitations of traditional single-outcome approaches.

Contribution

It proposes a set-valued dynamic treatment regime framework and an exact enumeration algorithm using linear mixed integer programming for multiple decision points.

Findings

Applied to depression and schizophrenia studies.

Effectively balances multiple clinical outcomes.

Provides a computational approach for complex treatment decision problems.

Abstract

Dynamic treatment regimes operationalize the clinical decision process as a sequence of functions, one for each clinical decision, where each function takes as input up-to-date patient information and gives as output a single recommended treatment. Current methods for estimating optimal dynamic treatment regimes, for example Q-learning, require the specification of a single outcome by which the `goodness' of competing dynamic treatment regimes are measured. However, this is an over-simplification of the goal of clinical decision making, which aims to balance several potentially competing outcomes. For example, often a balance must be struck between treatment effectiveness and side-effect burden. We propose a method for constructing dynamic treatment regimes that accommodates competing outcomes by recommending sets of treatments at each decision point. Formally, we construct a sequence of set-valued functions that take as input up-to-date patient information and give as output a recommended subset of the possible treatments. For a given patient history, the recommended set of treatments contains all treatments that are not inferior according to any of the competing outcomes. When there is more than one decision point, constructing these set-valued functions requires solving a non-trivial enumeration problem. We offer an exact enumeration algorithm by recasting the problem as a linear mixed integer program. The proposed methods are illustrated using data from a depression study and the CATIE schizophrenia study.