Critical adsorption controls translocation of polymer chains through lipid bilayers and permeation of solvent

TL;DR

This study uses Monte Carlo simulations to reveal how polymer chain adsorption near a lipid bilayer facilitates translocation and enhances solvent permeability, highlighting a critical transition point affecting membrane permeability.

Contribution

It introduces a new pathway for polymer translocation through lipid bilayers driven by adsorption transition, emphasizing the role of critical points in membrane permeability.

Findings

Membrane becomes transparent at the adsorption transition point.

Solvent permeability increases near the adsorption transition.

Polymer translocation is facilitated by the adsorption process.

Abstract

Monte Carlo simulations using an explicit solvent model indicate a new pathway for translocation of a polymer chain through a lipid bilayer. We consider a polymer chain composed of repeat units with a given hydrophobicity and a coarse-grained model of a lipid bilayer in the self-organized liquid state. By varying the degree of hydrophobicity the chain undergoes an adsorption transition with respect to the lipid bilayer. Close to the transition point, at a properly balanced hydrophobicity of the chain, the membrane becomes transparent with respect to the chain. At the same time the solvent permeability of the bilayer is strongly increased in the region close to adsorbed chain. Our results indicate that the critical point of adsorption of the polymer chain interacting with the fluctuating lipid bilayer could play a key role for the translocation of molecules though biological membranes.