Factorial graphical lasso for dynamic networks
E. C. Wit, A. Abbruzzo

TL;DR
This paper introduces a structured Gaussian dynamical graphical model for estimating sparse, time-dependent networks, improving accuracy and interpretability by incorporating temporal and structural constraints, with efficient optimization and model selection methods.
Contribution
It proposes a novel structured Gaussian dynamical graphical model that incorporates temporal dynamics and structural constraints, solved efficiently with convex optimization techniques.
Findings
Effective in identifying sparse dynamic networks
Improves estimation accuracy with structural constraints
Demonstrated on synthetic and real datasets
Abstract
Dynamic networks models describe a growing number of important scientific processes, from cell biology and epidemiology to sociology and finance. There are many aspects of dynamical networks that require statistical considerations. In this paper we focus on determining network structure. Estimating dynamic networks is a difficult task since the number of components involved in the system is very large. As a result, the number of parameters to be estimated is bigger than the number of observations. However, a characteristic of many networks is that they are sparse. For example, the molecular structure of genes make interactions with other components a highly-structured and therefore sparse process. Penalized Gaussian graphical models have been used to estimate sparse networks. However, the literature has focussed on static networks, which lack specific temporal constraints. We propose…
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Taxonomy
TopicsBioinformatics and Genomic Networks · Gene Regulatory Network Analysis · Gene expression and cancer classification
