The dynamics of the DNA denaturation transition
Titus S. van Erp, Michel Peyrard
TL;DR
This paper investigates the dynamics of DNA denaturation using a specific model, revealing how denaturation rates vary with temperature, sequence, and solvent friction, and highlighting the importance of base-pair order.
Contribution
It provides new insights into how DNA denaturation rates depend on length, temperature, sequence, and friction, using the Peyrard-Bishop-Dauxois model.
Findings
Denaturation rate decreases exponentially with length below Tc.
Above Tc, the rate has a minimum and then increases with length.
Sequence and solvent friction significantly influence opening rates.
Abstract
The dynamics of the DNA denaturation is studied using the Peyrard-Bishop-Dauxois model. The denaturation rate of double stranded polymers decreases exponentially as function of length below the denaturation temperature. Above Tc, the rate shows a minimum, but then increases as function of length. We also examine the influence of sequence and solvent friction. Molecules having the same number of weak and strong base-pairs can have significantly different opening rates depending on the order of base-pairs.
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