Phenomenon of irreducible genetic markers for TATAAA motifs in human chromosome 1

TL;DR

This paper introduces irreducible genetic markers (IG-markers) near TATAAA motifs in human chromosome 1, enabling precise identification of transcription start sites and proposing a universal mathematical method for locating DNA motifs.

Contribution

It presents a novel mathematical approach to identify IG-markers that determine the exact position of TATAAA motifs in DNA, aiding understanding of transcription initiation.

Findings

Identification of specific IG-markers near TATAAA motifs

IG-markers enable precise localization of TATAAA motifs

Proposed universal method for locating DNA motifs

Abstract

It is well known that the general transcription factors (GTF) specifically recognize correct TATA boxes, distinguishing them from many others. Employing the principles of determinacy analysis (mathematical theory of rules) we analyzed a fragment of human chromosome 1 DNA sequence and identified specific genetic markers (IG-markers = Irreducible Genetic markers) in the nearest proximity to TATAAA motifs. The IG-markers enable determining the exact location of any TATAAA motif within the investigated DNA fragment. Based on our data we hypothesize that the GTF recognize the {\guillemotleft}true{\guillemotright} transcriptional start TATA box by means of IG-markers. The math method described here is universal and can be used to find IG-markers that will provide, like a global navigation satellite system, for the specific location of any distinct sequence motif within larger DNA sequence content.