High-resolution Time-Of-Flight PET with Depth-Of-Interaction becomes feasible: a proof of principle

TL;DR

This paper demonstrates that with optimized scintillator surface treatment, electronics, and data algorithms, a high-resolution TOF-PET detector with DOI capability is feasible, achieving simultaneous excellent energy, timing, and depth resolution.

Contribution

It presents a proof of principle for a prostate TOF-PET probe with unprecedented combined resolution and performance, supporting future MRI-compatible PET imaging innovations.

Findings

Achieved 11.5% energy resolution

Achieved 150 ps TOF resolution

Achieved below 1 mm DOI resolution

Abstract

In this paper we prove that the choice of a suitable treatment of the scintillator surfaces, along with suitable photodetectors electronics and specific algorithms for raw data analysis, allow to achieve an optimal tradeoff between energy, time and DOI resolution, thus strongly supporting the feasibility of a prostate TOF- PET probe, MRI compatible, with the required features and performance. In numbers this means a detector element of 1.5mm x 1.5mm x 10mm, achieving at the same time energy resolution around 11.5%, time-of- flight resolution around 150 ps and DOI resolution even below 1 mm. We stress that such a time resolution allows to increase significantly the Noise Equivalent Counting Rate, and consequently improve the image quality and the lesion detection capability. These individual values correspond to the best obtained so far by other groups, but we got all of them simultaneously. In our opinion this proof of principle paves the way to the feasibility of a TOF-PET MRI compatible probe with unprecedented features and performance, not only innovative for prostate radiotracer imaging but possibly also for other organs.