Arrays of Nano-Electromechanical Biosensors Functionalized by Microcontact Printing

TL;DR

This paper introduces a modified microcontact printing technique for functionalizing large arrays of nanocantilevers, enhancing biosensor performance and integration by ensuring bioactivity, anti-fouling properties, and structural integrity.

Contribution

It presents a novel self-aligned microcontact printing method for nanostructure biofunctionalization, improving biosensor fabrication efficiency and reliability.

Findings

Successful biofunctionalization with antibodies and BSA molecules

Demonstrated anti-fouling properties of deposited layers

Preserved mechanical integrity of nanostructures

Abstract

The biofunctionalization of nanoelectromechanical structures is critical for the development of new classes of biosensors displaying improved performances and higher-level of integration. We propose a modified microcontact printing method for the functionalization and passivation of large arrays of nanocantilevers in a single, self-aligned step. Using fluorescence microscopy and resonant frequency measurements, we demonstrate (1) the bioactivity and the anti-fouling property of deposited antibodies and BSA molecules and (2) the preservation of the nanostructures' mechanical integrity.