CSA: Comprehensive comparison of pairwise protein structure alignments
Inken Wohlers (MAC4), No\"el Malod-Dognin (INRIA Sophia Antipolis),, Rumen Andonov (INRIA - IRISA), Gunnar W. Klau (MAC4)
TL;DR
CSA is a web server that provides comprehensive comparison of pairwise protein structure alignments, integrating multiple alignment methods and quality measures to enhance understanding of structural similarities.
Contribution
It introduces an exact alignment engine and a unified platform for comparing various protein structure alignments with visualizations and quality assessments.
Findings
Provides optimal and heuristic alignments with quality guarantees
Enables detailed comparison of contact map overlap, PAUL, DALI, and MATRAS alignments
Offers visualizations that reveal structural relationships
Abstract
CSA is a web server for the comprehensive comparison of pairwise protein structure alignments. Its exact alignment engine computes either optimal, top-scoring alignments or heuristic alignments with quality guarantee for the inter-residue distance based scorings of contact map overlap, PAUL, DALI and MATRAS. These and additional, uploaded alignments are compared using a number of quality measures and intuitive visualizations. CSA brings new insight into the structural relationship of the protein pairs under investigation and is a valuable tool for studying structural similarities. It is available at http://csa.project.cwi.nl
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