Cyclic Correlation of Diffuse Reflected Signal with Glucose Concentration and scatterer size

TL;DR

This study demonstrates that optical coherence tomography (OCT) signal intensity exhibits a cyclic correlation with glucose levels and scatterer size, validated through tissue phantoms and human blood samples.

Contribution

It introduces a novel analysis of OCT signal intensity revealing cyclic patterns related to glucose and scatterer size, supported by both theoretical calculations and in-vivo measurements.

Findings

OCT signal intensity cyclically correlates with glucose concentration.

The correlation depends on scatterer size.

The findings are validated in tissue phantoms and human blood samples.

Abstract

The utility of optical coherence tomography signal intensity for measurement of glucose concentration has been analysed in tissue phantom and blood samples from human subjects. The diffusion equation based calculations as well as in-vivo OCT signal measurements confirms the cyclic correlation of signal intensity with glucose concentration and scatterer size.