A neuroeconomic theory of bidirectional synaptic plasticity and addiction

TL;DR

This paper links economic models of addiction with neurobiological mechanisms, proposing that specific neural substrates influence addictive behaviors and suggesting future research directions in neuroeconomics and neuropsychiatry.

Contribution

It introduces a novel neuroeconomic framework connecting addiction theory with synaptic plasticity and identifies key neurobiological factors affecting addiction parameters.

Findings

Cortisol, NMDA, and AMPA receptors influence addiction parameters.

Neurobiological substrates are critical in economic models of addiction.

Future research directions in neuroeconomics and neuropsychiatry are discussed.

Abstract

Neuronal mechanisms underlying addiction have been attracting attention in neurobiology, economics, neuropsychiatry, and neuroeconomics. This paper proposes a possible link between economic theory of addiction (Becker and Murphy, 1988) and neurobiological theory of bidirectional synaptic plasticity (Bienenstock, Cooper, Munro, 1982) based on recent findings in neuroeconomics and neurobiology of addiction. Furthermore, it is suggested that several neurobiological substrates such as cortisol (a stress hormone), NMDA and AMPA receptors/subunits and intracellular calcium in the postsynaptic neurons are critical factors determining parameters in Becker and Murphy's economic theory of addiction. Future directions in the application of the theory to studies in neuroeconomics and neuropsychiatry of addiction and its relation to stress at the molecular level are discussed.