Signal Propagation in Feedforward Neuronal Networks with Unreliable Synapses

TL;DR

This study explores how unreliable synapses affect signal and firing rate propagation in feedforward neuronal networks, revealing the influence of synaptic parameters, noise, and inhibition on neural activity transmission.

Contribution

It provides a systematic analysis of unreliable synapses in feedforward networks, highlighting their impact on propagation stability and the role of inhibitory neurons, which was less explored in prior work.

Findings

Successful transmission probability and synaptic strength are crucial for stable propagation.

Noise can impair synfire precision but enhance firing rate propagation.

Inhibition significantly influences signal propagation in mixed neuronal networks.

Abstract

In this paper, we systematically investigate both the synfire propagation and firing rate propagation in feedforward neuronal network coupled in an all-to-all fashion. In contrast to most earlier work, where only reliable synaptic connections are considered, we mainly examine the effects of unreliable synapses on both types of neural activity propagation in this work. We first study networks composed of purely excitatory neurons. Our results show that both the successful transmission probability and excitatory synaptic strength largely influence the propagation of these two types of neural activities, and better tuning of these synaptic parameters makes the considered network support stable signal propagation. It is also found that noise has significant but different impacts on these two types of propagation. The additive Gaussian white noise has the tendency to reduce the precision of the synfire activity, whereas noise with appropriate intensity can enhance the performance of firing rate propagation. Further simulations indicate that the propagation dynamics of the considered neuronal network is not simply determined by the average amount of received neurotransmitter for each neuron in a time instant, but also largely influenced by the stochastic effect of neurotransmitter release. Second, we compare our results with those obtained in corresponding feedforward neuronal networks connected with reliable synapses but in a random coupling fashion. We confirm that some differences can be observed in these two different feedforward neuronal network models. Finally, we study the signal propagation in feedforward neuronal networks consisting of both excitatory and inhibitory neurons, and demonstrate that inhibition also plays an important role in signal propagation in the considered networks.