Is the general time-reversible model bad for molecular phylogenetics?
Jeremy Sumner, Peter Jarvis, Jesus Fernandez-Sanchez, Bodie Kaine,, Michael Woodhams, and Barbara Holland
TL;DR
This paper discusses potential issues with the widely used GTR model in molecular phylogenetics, highlighting mathematical concerns that could impact analysis accuracy.
Contribution
It provides examples illustrating the mathematical limitations of the GTR model and discusses their implications for phylogenetic inference.
Findings
GTR has a problematic mathematical property.
Examples show potential issues in phylogenetic analysis.
Implications for model choice in phylogenetics.
Abstract
The general time reversible model (GTR) is presently the most popular model used in phylogentic studies. However, GTR has an undesirable mathematical property that is potentially of significant concern. It is the purpose of this article to give examples that demonstrate why this deficit may pose a problem for phylogenetic analysis and interpretation.
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