Multiscale simulation of blood flow in brain arteries with an aneurysm

TL;DR

This paper demonstrates a multiscale simulation approach combining atomistic and continuum models to study blood flow and platelet aggregation in brain arteries with an aneurysm, utilizing high-performance computing.

Contribution

It introduces a coupled atomistic-continuum simulation framework applied to a patient-specific aneurysm model, integrating DPD and spectral/hp element Navier-Stokes methods.

Findings

Successful simulation on 190,000 processors

Modeling of platelet aggregation in aneurysm

First multiscale simulation of this kind

Abstract

Interfacing atomistic-based with continuum-based simulation codes is now required in many multiscale physical and biological systems. We present the first results from coupled atomistic-continuum simulations on 190,000 processors. Platelet aggregation in the patient-specific model of an aneurysm has been modeled using a high-order spectral/hp element Navier-Stokes solver with a stochastic (coarse-grained) Molecular Dynamics solver based on Dissipative Particle Dynamics (DPD).