Mixed Poisson distributions in exact solutions of stochastic auto-regulation models

TL;DR

This paper derives exact steady-state distributions for stochastic gene regulation models using the Poisson Representation, revealing how feedback strength influences distribution shapes and system behavior.

Contribution

It introduces a novel application of the Poisson Representation to obtain exact solutions for non-linear gene regulation models and analyzes how parameter variations affect distribution shapes.

Findings

Exact steady-state distributions for feedback models

Distribution shapes depend on parameter combinations

Feedback strength modulates noise characteristics

Abstract

In this paper we study the interplay between stochastic gene expression and system design using simple stochastic models of auto-activation and auto-inhibition. Using the Poisson Representation, a technique whose particular usefulness in the context of non-linear gene regulation models we elucidate, we find exact results for these feedback models in the steady state. Further, we exploit this representation to analyze the parameter spaces of each model, determine which dimensionless combinations of rates are the shape determinants for each distribution, and thus demarcate where in the parameter-space qualitatively different behaviors arise. These behaviors include power-law tailed distributions, bimodal distributions and sub-Poisson distributions. We also show how these distribution shapes change when the strength of the feedback is tuned. Using our results, we reexamine how well the auto-inhibition and auto-activation models serve their conventionally assumed roles as paradigms for noise suppression and noise exploitation, respectively.