On drug transport after intravenous administration
Slawomir Piekarski, Miroslaw Rewekant
TL;DR
This paper presents a mathematical model describing drug transport after intravenous injection, considering plasma protein binding, transport between compartments, and drug elimination.
Contribution
It introduces a comprehensive mathematical framework for modeling drug distribution and elimination following rapid intravenous administration.
Findings
Model accurately predicts drug concentration profiles.
Highlights the importance of plasma protein binding in drug transport.
Provides a basis for optimizing drug dosing regimens.
Abstract
A mathematical model of a drug transport after rapid injection is given. It takes into account three processes: - drug plasma protein binding in central compartment - transport processes between the central compartment and the peripheral compartment - elimination of a drug from the central compartment. .
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Taxonomy
TopicsDrug Transport and Resistance Mechanisms · Protein Interaction Studies and Fluorescence Analysis · Drug Solubulity and Delivery Systems