Subspace-based Identification Algorithm for Characterizing Causal Networks in Resting Brain

TL;DR

This paper introduces a novel subspace-based state-space system identification method to analyze causal brain networks in resting-state fMRI, addressing challenges posed by hemodynamic effects and noise.

Contribution

The paper presents a new algorithm for detecting effective connectivity in resting brain activity, focusing on latent neuronal interactions rather than observed BOLD signals.

Findings

The method reliably detects causal interactions in simulated data.

It is robust against network size and noise levels.

The approach advances causal analysis in resting-state brain studies.

Abstract

Analysis of brain activity in resting-state is of fundamental importance in identifying functional characteristics of neuronal system. Although resting brain has been extensively investigated for low frequency synchrony between brain regions, namely Functional Connectivity (FC), the other main stream of brain connectivity analysis that seeks causal interactions between brain regions, Effective Connectivity (EC), has been little explored in spontaneous brain oscillations. Inherent complexity of brain activities in resting-state, as is observed in BOLD (Blood Oxygenation-Level Dependant) fluctuations, call for exploratory methods for characterizing these causal networks. On the other hand, the inevitable effects that hemodynamic system imposes on causal inferences based on fMRI data, lead us toward the methods in which causal inferences can take place in latent neuronal level, rather than observed BOLD time-series. To simultaneously satisfy these two concerns, in this paper, we introduce a novel state-space system identification approach for studying causal interactions among brain regions in the absence of explicit cognitive task. Using extensive simulations, we study the effects of network size and signal to noise ratio (SNR) on the accuracy of our proposed method in EC detection. Our simulations demonstrate that Subspace-based Identification Algorithm (SIA) is sufficiently robust against above-mentioned factors, and can reliably unravel the underlying causal interactions of resting-state BOLD fMRI