Gain control in molecular information processing: Lessons from neuroscience

TL;DR

This paper explores how a simple gain control mechanism, inspired by neuroscience, can enhance molecular signaling fidelity without extra circuitry or feedback, explaining the prevalence of ultrasensitive responses in biology.

Contribution

It demonstrates that a gain control mechanism from neuroscience applies to molecular signaling, enabling high-fidelity information transmission without additional molecular complexity.

Findings

Gain control allows transmitting more than one bit of information.

The mechanism does not require feedback loops or extra circuitry.

It explains the abundance of ultrasensitive responses in biological networks.

Abstract

Statistical properties of environments experienced by biological signaling systems in the real world change, which necessitate adaptive responses to achieve high fidelity information transmission. One form of such adaptive response is gain control. Here we argue that a certain simple mechanism of gain control, understood well in the context of systems neuroscience, also works for molecular signaling. The mechanism allows to transmit more than one bit (on or off) of information about the signal independently of the signal variance. It does not require additional molecular circuitry beyond that already present in many molecular systems, and, in particular, it does not depend on existence of feedback loops. The mechanism provides a potential explanation for abundance of ultrasensitive response curves in biological regulatory networks.