Modules of human micro-RNA co-target network

TL;DR

This paper analyzes the community structure of the human micro-RNA co-target network, revealing it consists of approximately 74 modules that are self-organized to maximize modularity, reflecting complex gene regulation.

Contribution

It introduces a detailed community structure analysis of the miRNA co-target network, identifying approximately 74 modules and demonstrating their self-organized modularity.

Findings

The network contains about 74 modules.

Modules are similar to previously identified clusters.

The network's structure maximizes modularity.

Abstract

Human micro RNAs (miRNAs) target about 90% of the coding genes and form a complex regulatory network. We study the community structure of the miRNA co-target network considering miRNAs as the nodes which are connected by weighted links. The weight of link that connects a pair of miRNAs denote the total number of common transcripts targeted by that pair. We argue that the network consists of about 74 modules, quite similar to the components (or clusters) obtained earlier [Online J Bioinformatics, 10,280 ], indicating that the components of the miRNA co-target network are self organized in a way to maximize the modularity.