Accumulation of beneficial mutations in one dimension

TL;DR

This paper models beneficial mutation accumulation in a one-dimensional population, revealing a transition between regimes, surface growth analogies, and differences from well-mixed populations, highlighting effects of mutation rate and population size.

Contribution

Introduces a one-dimensional model for beneficial mutations, identifying a transition between selection regimes and surface growth dynamics, with key differences from well-mixed populations.

Findings

Transition between periodic selection and multiple-mutation regimes

Surface growth analogy with power law behavior

Reduced fixation rate at higher mutation rates and larger populations

Abstract

When beneficial mutations are relatively common, competition between multiple unfixed mutations can reduce the rate of fixation in well-mixed asexual populations. We introduce a one dimensional model with a steady accumulation of beneficial mutations. We find a transition between periodic selection and multiple-mutation regimes. In the multiple-mutation regime, the increase of fitness along the lattice bears a striking similarity to surface growth phenomena, with power law growth and saturation of the interface width. We also find significant differences compared to the well-mixed model. In our lattice model, the transition between regimes happens at a much lower mutation rate due to slower fixation times in one dimension. Also the rate of fixation is reduced with increasing mutation rate due to the more intense competition, and it saturates with large population size.