A simple model of cerebral blood flow dependence on arterial blood pressure

TL;DR

This paper presents a simple, adaptable model for cerebral blood flow dependence on arterial pressure, highlighting individual variability and a new observed decrease in flow with increased pressure.

Contribution

It introduces a linear feedback model encompassing classical autoregulation and emphasizes individual differences in cerebral blood flow regulation.

Findings

Model accurately describes dog experiment data

Reveals significant individual variability in feedback slope

Identifies a new decrease in CBF with rising MABP

Abstract

It is shown that the dependence of the cerebral blood flow (CBF) on mean arterial blood pressure (MABP) can be described with a simple model having the following assumptions. Below certain MABP (denoted as MABP1) there are no autoregulatory or feedback mechanisms influencing CBF. Between MABP1 and MABP2 (MABP at which breakthrough accurs) there is a linear (on MABP) dependent feedback with a sloap depending very much on the individual considered. The classical autoregulation model with a plateau in between MABP1 and MABP2 is a particular case of this model. The model describes well the experiments performed on dogs (Harper 1966), for which the individual feedback sloap parameter varied to great extent, indicating the importance of mesurments on individuals against averaged mesurments (or measurments on diffent individuals) which superficially support the classical autoregulation. New effect of decreased CBF, while increasing MABP, was observed.