Cell motility: a viscous fingering analysis of active gels

TL;DR

This paper models keratocyte cell motility using active gel theory and viscous fingering, demonstrating how actin network symmetry breaking drives movement and deriving velocity based on filament orientation.

Contribution

It introduces an analytical model linking actin cortex reorganization and cell motility through active gel theory and viscous fingering analysis.

Findings

Reorganization of the actin cortex explains cell motility.

Velocity depends on the orientation order parameter.

Analytical expressions for cell velocity are derived.

Abstract

The symmetry breaking of the actin network from radial to longitudinal symmetry has been identified as the major mechanism for keratocytes (fish cells) motility on solid substrate. For strong friction coefficient, the two dimensional actin flow which includes the polymerisation at the edge and depolymerisation in the bulk can be modelled as a Darcy flow, the cell shape and dynamics being then modelled by standard complex analysis methods. We use the theory of active gels to describe the orientational order of the filaments which varies from the border to the bulk. We show analytically that the reorganisation of the cortex is enough to explain the motility of the cell and find the velocity as a function of the orientation order parameter in the bulk.